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Is there a lethal dose for cannabis?

  • Writer: tonyrgallo
    tonyrgallo
  • Jul 1, 2014
  • 1 min read

Is there a lethal dose for cannabis?

The LD50 is a classic toxicological data point defined as the dose required to kill 50 % of the subjects in a test population. The LD50 of THC is currently unknown but one report has indicated that it is theoretically between 15 and 70 grams for the average human (150 lb). Let’s put this into perspective. The casual user (once a month or so) generally only needs about 2-3 mg of THC to become intoxicated, while habitual users may need between five and ten times that amount to reach intoxication. Since 2 mg = 0.002 g, a casual user would need to smoke about 5000 times (15g / .002g) their normal amount to approach a potentially lethal dose.

A separate report estimates that the LD50 of cannabis is approximately 1:20,000 or 1:40,000. In other words, in order to induce death, an individual would have to consume 20,000 to 40,000 times as much cannabis as is contained in one cannabis cigarette. The National Institute on Drug Abuse (NIDA) supplies cannabis cigarettes that weigh approximately 0.7 to 1 gram. One would theoretically have to consume approximately 1,500 pounds of cannabis within about fifteen minutes to induce a lethal response.

- Read more at: http://blog.quantum9.net/why-has-no-one-died-from-cannabis-%E2%80%93-pharmacology-perspective?sthash.hXtabPCv.mjjo


 
 
 

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